Занимается разработкой генно-инженерных препаратов на основе аллогенных T-лимфоцитов для лечения злокачественных опухолей. Лекарства производятся на основе T-лимфоцитов здоровых доноров, и их можно вводить любому человеку в отличие от препаратов на показать больше
основе аутологичных T-лимфоцитов, которые можно вводить только тому пациенту, от которого были получены эти клетки. Сейчас все препараты находятся в разработке, соответственно прибыли у компании нет.
Allogene Therapeutics, Inc., a clinical stage immuno-oncology company, develops and commercializes genetically engineered allogeneic T cell therapies for the treatment of cancer. It develops, manufactures, and commercializes UCART19, an allogeneic chimeric antigen receptor (CAR) T cell product candidate for the treatment of pediatric and adult patients with R/R CD19 positive B-cell ALL. The company also develops ALLO-501, an anti-CD19 allogeneic CAR T cell product candidate that is in Phase I clinical trial for the treatment of R/R non-Hodgkin lymphoma and ALLO-501A, which is in Phase I/II clinical trial for the treatment R/R large B-cell lymphoma or transformed follicular lymphoma. In addition, it is developing ALLO-715, an allogeneic CAR T cell product candidate that is in a Phase I clinical trial for treating R/R multiple myeloma ALLO-819, an allogeneic CAR T cell product candidates for the treatment of acute myeloid leukemia ALLO-605, an allogeneic CAR T cell product candidate for the treatment of multiple myeloma ALLO-647, an anti-CD52 monoclonal antibody CD70 to treat renal cell cancer and DLL3 for the treatment of small cell lung cancer and other aggressive neuroendocrine tumors. The company has license and collaboration agreements with Pfizer Inc. Servier Cellectis S.A. and Notch Therapeutics Inc., as well as clinical trial collaboration agreement with SpringWorks Therapeutics, Inc. It also has a strategic collaboration agreement with The University of Texas MD Anderson Cancer Center for the preclinical and clinical investigation of allogeneic CAR T cell product candidates. The company was founded in 2017 and is headquartered in South San Francisco, California.